HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-acetylamino-3-(4-benzyloxy-3-chloro-5-methyl-phenyl)-acrylate → Methyl 2-acetylamino-3-(3-chloro-4-hydroxy-5-methyl-phenyl)-propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-acetylamino-3-(4-benzyloxy-3-chloro-5-methyl-phenyl)-acrylate | HCID 68673687 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 2-acetylamino-3-(3-chloro-4-hydroxy-5-methyl-phenyl)-propionate | HCID 68674685 | — |
Reaction Steps
A mixture of 7.40 g (19.8 mmol) methyl 2-acetylamino-3-(4-benzyloxy-3-chloro-5-methyl-phenyl)-acrylate, 300 mL MeOH and 800 mg Raney nickel was shaken at RT and 3000 hPa hydrogen pressure for 7 h. After the reaction had ended the catalyst was filtered off and the remainder was evaporated down i.vac.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07696209B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-dc7814f123324f9180d198aaf31bdc9a |
| Source note | uspto-grants-2010_04 |