1-(Oxan-4-yl)piperazine → HCID 86609031, compound

HRID 643125Notes

Reaction equation

HRID 643125 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:10][C@@H:11]([NH:15][C:16]([N:18]2[CH2:23][CH2:22][CH:21]([N:24]3[CH2:30][CH2:29][C:28]4[CH:31]=[CH:32][CH:33]=[CH:34][C:27]=4[NH:26][C:25]3=[O:35])[CH2:20][CH2:19]2)=[O:17])[C:12]([OH:14])=O)[CH:5]=[C:6]([CH3:9])[C:7]=1[OH:8].[O:36]1[CH2:41][CH2:40][CH:39]([N:42]2[CH2:47][CH2:46][NH:45][CH2:44][CH2:43]2)[CH2:38][CH2:37]1>>[O:35]=[C:25]1[N:24]([CH:21]2[CH2:22][CH2:23][N:18]([C:16]([O-:17])=[O:36])[CH2:19][CH2:20]2)[CH2:30][CH2:29][C:28]2[CH:31]=[CH:32][CH:33]=[CH:34][C:27]=2[NH:26]1.[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[C:6]([CH3:9])[C:7]=1[OH:8])[CH2:10][C@@H:11]([NH-:15])[C:12](=[O:14])[N:45]1[CH2:44][CH2:43][N:42]([CH:39]2[CH2:40][CH2:41][O:36][CH2:37][CH2:38]2)[CH2:47][CH2:46]1

Participants

3

Reactant 2

HCID 219423151-(Oxan-4-yl)piperazineHCID 68675127HCID 68675127, compound

Product 1

HCID 86609031HCID 86609031, compound

Procedure

Prepared analogously to Example 7i from 70 mg (0.14 mmol) (R)-3-(3-chloro-4-hydroxy-5-methyl-phenyl)-2-{[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carbonyl]-amino}-propionic acid and 27.4 mg (0.16 mmol) 1-(tetrahydropyran-4-yl)-piperazine.

Sources & evidence

ORD record
ord-3c216595611843e794a737ac8e095636
Source dataset
uspto-grants-2010_04
Patent number
US07696209B2

Reaction notes

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