1-(Oxan-4-yl)piperazine → HCID 11857619, compound

HRID 643129Notes

Reaction equation

HRID 643129 reaction equation
[O:1]=[C:2]1[N:8]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C@@H:18]([C:29](O)=[O:30])[CH2:19][C:20]3[CH:25]=[C:24]([CH3:26])[C:23]([OH:27])=[C:22]([Cl:28])[CH:21]=3)=[O:16])[CH2:11][CH2:10]2)[CH2:7][CH2:6][C:5]2[CH:32]=[CH:33][CH:34]=[CH:35][C:4]=2[NH:3]1.[O:36]1[CH2:41][CH2:40][CH:39]([N:42]2[CH2:47][CH2:46][NH:45][CH2:44][CH2:43]2)[CH2:38][CH2:37]1>>[O:1]=[C:2]1[N:8]([CH:9]2[CH2:10][CH2:11][N:12]([C:15]([O:17][C@H:18]([CH2:19][C:20]3[CH:25]=[C:24]([CH3:26])[C:23]([OH:27])=[C:22]([Cl:28])[CH:21]=3)[C:29](=[O:30])[N:45]3[CH2:44][CH2:43][N:42]([CH:39]4[CH2:40][CH2:41][O:36][CH2:37][CH2:38]4)[CH2:47][CH2:46]3)=[O:16])[CH2:13][CH2:14]2)[CH2:7][CH2:6][C:5]2[CH:32]=[CH:33][CH:34]=[CH:35][C:4]=2[NH:3]1

Participants

3

Reactant 2

HCID 219423151-(Oxan-4-yl)piperazineHCID 66941742HCID 66941742, compound

Product 1

HCID 11857619HCID 11857619, compound

Procedure

Prepared analogously to Example 7i from 80 mg (0.16 mmol) (R)-1-carboxy-2-(3-chloro-4-hydroxy-5-methyl-phenyl)-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate and 29.8 mg (0.18 mmol) 1-(tetrahydropyran-4-yl)-piperazine.

Sources & evidence

ORD record
ord-67156fab6c6643e9a98a17d4b59d8427
Source dataset
uspto-grants-2010_04
Patent number
US07696209B2

Reaction notes

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