1-(Oxan-4-yl)piperazine → HCID 11857621, compound

HRID 643132Notes

Reaction equation

HRID 643132 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:31]=[C:32]([CH3:35])[C:33]=1[OH:34])[CH2:5][C@@H:6]([CH2:10][C:11](=[O:30])[N:12]1[CH2:17][CH2:16][CH:15]([N:18]2[CH2:24][CH2:23][C:22]3[CH:25]=[CH:26][CH:27]=[CH:28][C:21]=3[NH:20][C:19]2=[O:29])[CH2:14][CH2:13]1)[C:7]([OH:9])=O.[O:36]1[CH2:41][CH2:40][CH:39]([N:42]2[CH2:47][CH2:46][NH:45][CH2:44][CH2:43]2)[CH2:38][CH2:37]1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:31]=[C:32]([CH3:35])[C:33]=1[OH:34])[CH2:5][C@@H:6]([CH2:10][C:11]([N:12]1[CH2:17][CH2:16][CH:15]([N:18]2[CH2:24][CH2:23][C:28]3[CH:27]=[CH:26][CH:25]=[CH:22][C:21]=3[NH:20][C:19]2=[O:29])[CH2:14][CH2:13]1)=[O:30])[C:7]([N:45]1[CH2:44][CH2:43][N:42]([CH:39]2[CH2:40][CH2:41][O:36][CH2:37][CH2:38]2)[CH2:47][CH2:46]1)=[O:9]

Participants

3

Reactant 2

HCID 219423151-(Oxan-4-yl)piperazineHCID 68674204HCID 68674204, compound

Product 1

HCID 11857621HCID 11857621, compound

Procedure

Prepared analogously to Example 7i from 100 mg (0.20 mmol) (S)-2-(3-chloro-4-hydroxy-5-methyl-benzyl)-4-oxo-4-[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-butanoic acid and 37.5 mg (0.22 mmol) 1-(tetrahydropyran-4-yl)-piperazine.

Sources & evidence

ORD record
ord-301af5ac3d0c4237a0ee454d2230eb20
Source dataset
uspto-grants-2010_04
Patent number
US07696209B2

Reaction notes

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