1-(Oxan-4-yl)piperazine → HCID 57674050, compound

HRID 643140Notes

Reaction equation

[NH2:1][C:2]1[C:33]([CH3:34])=[CH:32][C:5]([CH2:6][C@@H:7]([CH2:11][C:12](=[O:31])[N:13]2[CH2:18][CH2:17][CH:16]([N:19]3[CH2:25][CH2:24][C:23]4[CH:26]=[CH:27][CH:28]=[CH:29][C:22]=4[NH:21][C:20]3=[O:30])[CH2:15][CH2:14]2)[C:8](O)=[O:9])=[CH:4][C:3]=1[Cl:35].[O:36]1[CH2:41][CH2:40][CH:39]([N:42]2[CH2:47][CH2:46][NH:45][CH2:44][CH2:43]2)[CH2:38][CH2:37]1>>[NH2:1][C:2]1[C:33]([CH3:34])=[CH:32][C:5]([CH2:6][C@@H:7]([CH2:11][C:12]([N:13]2[CH2:14][CH2:15][CH:16]([N:19]3[CH2:25][CH2:24][C:23]4[CH:26]=[CH:27][CH:28]=[CH:29][C:22]=4[NH:21][C:20]3=[O:30])[CH2:17][CH2:18]2)=[O:31])[C:8]([N:45]2[CH2:46][CH2:47][N:42]([CH:39]3[CH2:40][CH2:41][O:36][CH2:37][CH2:38]3)[CH2:43][CH2:44]2)=[O:9])=[CH:4][C:3]=1[Cl:35]

Participants

Reactant 2

HCID 219423151-(Oxan-4-yl)piperazine

HCID 68675179HCID 68675179, compound

Product 1

HCID 57674050HCID 57674050, compound

Procedure

Prepared analogously to Example 7i from 70 mg (0.14 mmol) (S)-2-(4-amino-3-chloro-5-methyl-benzyl)-4-oxo-4-[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-butanoic acid and 27 mg (0.16 mmol) 1-(tetrahydropyran-4-yl)-piperazine.

Sources & evidence

ORD record: ord-3301f0cb00614d6f9b0af80bd72defdf
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07696209B2

Reaction notes

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