反应详情

温度

180 °C

10.0 g (45.4 mmol) 4-methoxy-3-trifluoromethyl-benzoic acid and 75 g pyridinium-hydrochloride were mixed well and then heated to 180° C. under a nitrogen atmosphere for 5 h. The reaction mixture was poured onto 1 L 10% citric acid solution and extracted with 50 mL EtOAc. The organic phase was washed with 1 L water and dried over Na2SO4. After the desiccant and solvent had been eliminated the product was further reacted without purification.

1. extractionextracted with 50 mL EtOAc
2. washThe organic phase was washed with 1 L water
3. dry with materialdried over Na2SO4
4. customwas further reacted without purification