Citric Acid → 4-Hydroxy-3-(trifluoromethyl)benzoic acid
Reaction equation
C[O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:4]=1[C:12]([F:15])([F:14])[F:13].C(O)(=O)CC(CC(O)=O)(C(O)=O)O>>[OH:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:4]=1[C:12]([F:13])([F:14])[F:15]Participants
3
Conditions
- Temperature
- 180 °C
Procedure
10.0 g (45.4 mmol) 4-methoxy-3-trifluoromethyl-benzoic acid and 75 g pyridinium-hydrochloride were mixed well and then heated to 180° C. under a nitrogen atmosphere for 5 h. The reaction mixture was poured onto 1 L 10% citric acid solution and extracted with 50 mL EtOAc. The organic phase was washed with 1 L water and dried over Na2SO4. After the desiccant and solvent had been eliminated the product was further reacted without purification.
Workup
- extractionextracted with 50 mL EtOAc
- washThe organic phase was washed with 1 L water
- dry with materialdried over Na2SO4
- customwas further reacted without purification
Sources & evidence
- ORD record
- ord-0119ea6717684e4dbe98ae0128d4edbf
- Source dataset
- uspto-grants-2010_04
- Patent number
- US07696209B2
Reaction notes
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