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HRID 643151作成日：2026年10月25日

1-(Oxan-4-yl)piperazine → (S)-2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-4-[4-(6-hydroxy-2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-1-[4-(tetrahydropyran-4-yl)-piperazin-1-yl]-butane-1,4-dione

https://huagongshe.com/reaction/643151

反応式

関与物質

役割名称HCID仕込み量
反応物1-(Oxan-4-yl)piperazineHCID 21942315—
反応物(S)-2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-4-[4-(6-hydroxy-2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-4-oxo-butanoic acidHCID 68676153—
生成物(S)-2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-4-[4-(6-hydroxy-2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-1-[4-(tetrahydropyran-4-yl)-piperazin-1-yl]-butane-1,4-dioneHCID 57674019—

反応手順

Prepared analogously to Example 8i from 80.0 mg (0.14 mmol) (S)-2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-4-[4-(6-hydroxy-2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-4-oxo-butanoic acid and 24.5 mg (0.14 mmol) 1-(tetrahydropyran-4-yl)-piperazine.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07696209B2
出典データセットuspto-grants-2010_04
ORD IDord-0fef745665704d3ca73c57a613fb6a26
出典メモuspto-grants-2010_04