1-(Oxan-4-yl)piperazine → HCID 57674012, compound

HRID 643152Notes

Reaction equation

HRID 643152 reaction equation
[NH2:1][C:2]1[C:35]([C:36]([F:39])([F:38])[F:37])=[CH:34][C:5]([CH2:6][C@@H:7]([CH2:11][C:12](=[O:33])[N:13]2[CH2:18][CH2:17][CH:16]([N:19]3[C:23]4[CH:24]=[N:25][C:26]5[CH:27]=[CH:28][CH:29]=[CH:30][C:31]=5[C:22]=4[NH:21][C:20]3=[O:32])[CH2:15][CH2:14]2)[C:8]([OH:10])=O)=[CH:4][C:3]=1[Cl:40].[O:41]1[CH2:46][CH2:45][CH:44]([N:47]2[CH2:52][CH2:51][NH:50][CH2:49][CH2:48]2)[CH2:43][CH2:42]1>>[NH2:1][C:2]1[C:35]([C:36]([F:39])([F:37])[F:38])=[CH:34][C:5]([CH2:6][C@@H:7]([CH2:11][C:12]([N:13]2[CH2:14][CH2:15][CH:16]([N:19]3[C:23]4[CH:24]=[N:25][C:26]5[CH:27]=[CH:28][CH:29]=[CH:30][C:31]=5[C:22]=4[NH:21][C:20]3=[O:32])[CH2:17][CH2:18]2)=[O:33])[C:8]([N:50]2[CH2:49][CH2:48][N:47]([CH:44]3[CH2:45][CH2:46][O:41][CH2:42][CH2:43]3)[CH2:52][CH2:51]2)=[O:10])=[CH:4][C:3]=1[Cl:40]

Participants

3

Reactant 2

HCID 219423151-(Oxan-4-yl)piperazineHCID 68590752HCID 68590752, compound

Product 1

HCID 57674012HCID 57674012, compound

Procedure

Prepared analogously to Example 7i from 80 mg (0.14 mmol) (S)-2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-4-oxo-4-[4-(2-oxo-1,2-dihydro-imidazo[4,5-c]quinolin-3-yl)-piperidin-1-yl]-butanoic acid and 26.0 mg (0.15 mmol) 1-(tetrahydropyran-4-yl)-piperazine.

Sources & evidence

ORD record
ord-b9d0571d3a8b4f7e90eff8fc3df19447
Source dataset
uspto-grants-2010_04
Patent number
US07696209B2

Reaction notes

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