Dimethyl Sulfoxide → HCID 86606155, compound

Participants

Reaction Steps

The reaction of 54 mg (0.12 mmol) of compound 5 in 3 mL dry DMSO with 27 μL ethanethiol (0.36 mmol) was carried out according to the same protocol used to obtain compound 7, giving compound 8 in 83% yield (58 mg, 0.1 mmol). FTIR (KBr) (cm−1): 3000, 1727, 1622, 600. 1H-NMR (DMSO-d6): δ (ppm) 8.24 (s, 1H), 7.53 (d, J=2.63, 1H), 7.36 (dd, J=9.24 Hz, J=2.67 Hz, 1H), 7.24 (d, J=9.24 Hz, 1H), 4.38 (d, 1H), 4.32 (s, 1H), 4.00 (s, 3H), 3.98 (d, J=5.6 Hz, 3H), 3.92 (d, J=5.4 Hz, 1H), 3.87 (d, J=5.6 Hz, 1H), 2.80 (m, 4H), 1.30 (t, J=7.24 Hz, 6H). 13C-NMR (DMSO-d6): δ (ppm) 175.06, 172.67, 168.06, 158.44, 150.63, 137.28, 128.83, 128.32, 124.22, 119.69, 118.47, 117.21, 50.01, 46.23, 42.16, 39.12, 14.24, 12.02. HRMS expected for C25H24N2O10S2: 576.087238; found: 576.087413.

Provenance & Evidence