Dimethyl Sulfoxide → HCID 86606155, compound

Participants

Reaction Steps

The reaction of 44 mg (0.12 mmol) of compound 6 in 3 mL dry DMSO with 27 μL ethanethiol (0.36 mmol) was carried out according to the same protocol used to obtain compound 7, giving compound 9 in 84% yield (49 mg, 0.1 mmol). FTIR (KBr) (cm−1): 1720, 1620, 600. 1H-NMR (CDCl3): δ (ppm) 8.21 (s, 1H), 7.57 (d, J=2.53 Hz, 1H), 7.39 (dd, J=8.47 Hz, J=2.67 Hz, 1H), 7.26 (d, J=8.35 Hz, 1H), 3.84 (s, 1H), 3.12 (s, 1H), 3.07 (s, 1H, 2.83 (m, 4H), 1.93 (d, J=7.08 Hz, 3H), 1.90 (d, J=7.25 Hz, 3H), 1.30 (t, J=7.28 Hz, 6H). 13C-NMR (DMSO-d6): δ (ppm) 175.04, 172.32, 167.92, 156.34, 150.73, 137.21, 129.87, 128.65, 124.34, 118.03, 117.04, 38.53, 34.29, 26.02, 20.68, 14.27, 11.67. HRMS expected for C23H24N2O6S2: 488.107580; found: 488.107213.

Provenance & Evidence