HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 68578970, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (Pyrimidin-5-yl)boronic acid | HCID 2795193 | — |
| Reactant | 4-(2-bromophenyl)morpholine | HCID 5325729 | — |
| Catalyst | Palladium Chloride | HCID 24290 | — |
| Catalyst | Ferrocene-1,1'-bis-(diphenylphosphine) | HCID 635956 | — |
| Product | HCID 68578970 | HCID 68578970 | — |
Reaction Steps
In a manner similar to those previously described (Examples 15-17, 67), 6-bromophenyl morpholine (67C) was treated with pyrimidine-5-boronic acid, PdCl2(dppf, and K2CO3, to provide compound 6-(pyrimidin-5-yl)-benzomorpholine, which was further converted to the title compound 68. MS m/z 294 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07700592B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-8555efbca531467bae767978bf074fc3 |
| Source note | uspto-grants-2010_04 |