3-(8-Chloro-3-phenyl-cinnolin-4-yl)-phenylamine → 8-Chloro-4-(3-{[5-chloro-2-(trifluoromethyl)benzyl]oxy}phenyl)-3-phenylcinnoline

HRID 643310Notes

Reaction equation

HRID 643310 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[N:9][C:8]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[C:7]2[C:18]1[CH:19]=[C:20](N)[CH:21]=[CH:22][CH:23]=1.[Cl:25][C:26]1[CH:27]=[CH:28][C:29]([C:34]([F:37])([F:36])[F:35])=[C:30]([CH:33]=1)[CH:31]=[O:32]>>[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[N:9][C:8]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[C:7]2[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([O:32][CH2:31][C:30]2[CH:33]=[C:26]([Cl:25])[CH:27]=[CH:28][C:29]=2[C:34]([F:37])([F:35])[F:36])[CH:19]=1

Participants

3

Reactant 2

HCID 118566993-(8-Chloro-3-phenyl-cinnolin-4-yl)-phenylamineHCID 177507585-Chloro-2-(trifluoromethyl)benzaldehyde

Product 1

HCID 452732408-Chloro-4-(3-{[5-chloro-2-(trifluoromethyl)benzyl]oxy}phenyl)-3-phenylcinnoline

Procedure

The title compound was prepared from 3-(8-chloro-3-phenyl-cinnolin-4-yl)-phenylamine and 5-chloro-2-trifluoromethylbenzaldehyde according to the procedure of Step 5 Example 6. MS (ES) m/z 525.1.

Sources & evidence

ORD record
ord-c9311ccfcfbb4d7597e5ee7204a8046b
Source dataset
uspto-grants-2010_04
Patent number
US07700595B2

Reaction notes

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