alpha-Bromo-o-chlorotoluene → 3-Benzyl-8-chloro-4-{3-[(2-chlorobenzyl)oxy]phenyl}cinnoline

HRID 643334Notes

Reaction equation

HRID 643334 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[N:9][C:8](C1C=CC=CC=1)=[C:7]2[C:18]1[CH:19]=[C:20]([OH:24])[CH:21]=[CH:22][CH:23]=1.[Cl:25][C:26]1[CH:33]=[CH:32][CH:31]=[CH:30][C:27]=1[CH2:28]Br>>[CH2:7]([C:8]1[N:9]=[N:10][C:11]2[C:6]([C:7]=1[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH2:28][C:27]3[CH:30]=[CH:31][CH:32]=[CH:33][C:26]=3[Cl:25])[CH:19]=1)=[CH:5][CH:4]=[CH:3][C:2]=2[Cl:1])[C:6]1[CH:11]=[CH:2][CH:3]=[CH:4][CH:5]=1

Participants

3

Reactant 2

HCID 11905alpha-Bromo-o-chlorotolueneHCID 118564393-(8-Chloro-3-phenylcinnolin-4-yl)phenol

Product 1

HCID 118543163-Benzyl-8-chloro-4-{3-[(2-chlorobenzyl)oxy]phenyl}cinnoline

Procedure

The title compound was prepared from 3-(8-chloro-3-phenyl-cinnolin-4-yl)-phenol and 2-chlorobenzyl bromide according the procedure of Example 14. MS (ES) m/z 470.8.

Sources & evidence

ORD record
ord-0c2082057bac489daaf41a1781d9d5d1
Source dataset
uspto-grants-2010_04
Patent number
US07700595B2

Reaction notes

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