Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Reactant | 1-(2-Amino-3-trifluoromethyl-phenyl)-3-phenyl-propan-1-one | HCID 68579118 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | HCID 178515565 | HCID 178515565 | — |
Reaction Steps
To a solution of 1-(2-amino-3-trifluoromethyl-phenyl)-3-phenyl-propan-1-one (4.2 g, 13.8 mmol) in AcOH (70 ml) and H2SO4 (10 ml) was added a solution of NaNO2 (1.8 g in 10 ml H2O). The reaction was then heated to 70° C. After 1.5 hr, the reaction was cooled, poured into water and extracted with EtOAc. The organic layer was dried (MgSO4) and concentrated to give 3-benzyl-8-trifluoromethyl-cinnolin-4-ol
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07700595B2 |
|---|
| Source dataset | uspto-grants-2010_04 |
|---|
| ORD ID | ord-dca9a4535cc44a9fbef1f4f1812445ee |
|---|
| Source note | uspto-grants-2010_04 |
|---|
