HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxy-2,7-naphthyridine → 6-Methoxy-1,2,3,4-tetrahydro-2,7-naphthyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxy-2,7-naphthyridine | HCID 59164398 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 6-Methoxy-1,2,3,4-tetrahydro-2,7-naphthyridine | HCID 59164394 | — |
Reaction Steps
Crude 3-methoxy-2,7-naphthyridine (prepared from 4.4 mmol of 6-methoxy-4-[(trimethylsilyl)ethynyl]nicotinaldehyde) was hydrogenated (30 psi pressure) at RT over PtO2 (approx. 0.1 g) in HOAc (25 mL) for 2.5 h. The solution was filtered through a Celite pad and the clear filtrate was concentrated by freeze-drying to give crude 6-methoxy-1,2,3,4-tetrahydro-2,7-naphthyridine as the acetate salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07700604B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-12652df9eabe4af0829eb15bf312f531 |
| Source note | uspto-grants-2010_04 |