Methyl 2-chloro-4-nitrobenzoate → 8-Amino-5-oxo-2-(4-phenoxyphenyl)-4,5-dihydropyrazolo[1,5-a]quinazoline-3-carboxamide

反応式

Cl[C:2]1[CH:11]=[C:10]([N+:12]([O-])=O)[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=O.[NH2:15][C:16]1[NH:20][N:19]=[C:18]([C:21]2[CH:26]=[CH:25][C:24]([O:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)=[CH:23][CH:22]=2)[C:17]=1[C:34]([NH2:36])=[O:35]>>[NH2:12][C:10]1[CH:11]=[C:2]2[C:3]([C:4](=[O:6])[NH:15][C:16]3[N:20]2[N:19]=[C:18]([C:21]2[CH:22]=[CH:23][C:24]([O:27][C:28]4[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=4)=[CH:25][CH:26]=2)[C:17]=3[C:34]([NH2:36])=[O:35])=[CH:8][CH:9]=1

参加物

反応物 2

HCID 83343Methyl 2-chloro-4-nitrobenzoate

HCID 178513497HCID 178513497、化合物

生成物 1

HCID 1369281488-Amino-5-oxo-2-(4-phenoxyphenyl)-4,5-dihydropyrazolo[1,5-a]quinazoline-3-carboxamide

実験手順

The desired product was prepared from methyl 2-chloro-4-nitrobenzoate and 5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide using the procedures similar to those for compound 76 and 77. 1H NMR (400 MHz, DMSO-d6) δ 10.61 (s, 1H), 7.77 (d, J=8.4 Hz, 1H), 7.71 (d, J=8.0 Hz, 2H), 7.44-7.36 (m, 2H), 7.19-7.02 (m, 6H), 6.64 (d, J=8.4 Hz, 1H), 6.55 (br s, 2H). MS (ESI, m/e) [M+1]+ 412.1.

出典と根拠

ORDレコード: ord-08a3b16077e345bb95cae13fff129821
出典データセット: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09447106B2

反応ノート

読み込み中…