反应详情

(1S)—N-[2-tert-butoxy-5-(trifluoromethyl)benzyl]-1-isopropyl-4-oxocyclopent-2-ene-1-carboxamide (32 g, 80.6 mmol) was dissolved in MeOH and was hydrogenated for 18 hr with a hydrogen balloon in the presence of a catalytic amount of 10% palladium on carbon. The palladium was filtered through a celite plug. The filtrate was evaporated to dryness to give (1S)—N-[2-tert-butoxy-5-(trifluoromethyl)benzyl]-1-isopropyl-3-oxocyclopentanecarboxamide as a yellow solid.

1. filtrationThe palladium was filtered through a celite plug
2. customThe filtrate was evaporated to dryness