HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-Fluoro-5-nitrobenzoate → Methyl 5-amino-2-fluorobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-Fluoro-5-nitrobenzoate | HCID 11217860 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 5-amino-2-fluorobenzoate | HCID 15621043 | — |
Reaction Steps
A mixture of methyl 2-fluoro-5-nitrobenzoate (14.52 g, 72.92 mmol) and Pd/C (10%, Degussa type, 726 mg) in methanol was agitated under 60 psi of H2 using a Parr apparatus for 3 h. The reaction mixture was filtered and the filtrate was concentrated to give methyl 5-amino-2-fluorobenzoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07700591B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-162465042c5548059eb1102b9dc0849d |
| Source note | uspto-grants-2010_04 |