HCID 86632305, compound → HCID 57529756, compound

HRID 643628Notes

Reaction equation

HRID 643628 reaction equation
[O:1]=[C:2]1[N:8]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C@H:18]([CH2:40][C:41]3[CH:46]=[CH:45][C:44]([OH:47])=[CH:43][CH:42]=3)[C:19]([N:21]3[CH2:26][CH2:25][N:24]([CH:27]4[CH2:32][CH2:31][N:30](OC(C)(C)C)[C:29](=C=O)[CH2:28]4)[CH2:23][CH2:22]3)=[O:20])=[O:16])[CH2:11][CH2:10]2)[CH2:7][CH2:6][C:5]2[CH:48]=[CH:49][CH:50]=[CH:51][C:4]=2[NH:3]1>C(O)=O>[O:1]=[C:2]1[N:8]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C@H:18]([CH2:40][C:41]3[CH:42]=[CH:43][C:44]([OH:47])=[CH:45][CH:46]=3)[C:19](=[O:20])[N:21]3[CH2:22][CH2:23][N:24]([CH:27]4[CH2:28][CH2:29][NH:30][CH2:31][CH2:32]4)[CH2:25][CH2:26]3)=[O:16])[CH2:11][CH2:10]2)[CH2:7][CH2:6][C:5]2[CH:48]=[CH:49][CH:50]=[CH:51][C:4]=2[NH:3]1

Participants

3

Reactant 1

HCID 86632305HCID 86632305, compound

Product 1

HCID 57529756HCID 57529756, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

To a solution of 210 mg (0.30 mmol) of (R)-1-(4-hydroxy-benzyl)-2-[4-(1-tert-butoxy-carbonyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate (Example 124) in 1.5 mL formic acid was stirred for 3 h at RT. The reaction mixture was evaporated down i.vac. and the residue was purified by chromatography (silica gel, DCM/MeOH/NH3 90:10:1).

Workup

  1. customThe reaction mixture was evaporated down i.vac
  2. customand the residue was purified by chromatography (silica gel, DCM/MeOH/NH3 90:10:1)

Sources & evidence

ORD record
ord-6e254579fc114410b59b0113865681c5
Source dataset
uspto-grants-2010_04
Patent number
US07700598B2

Reaction notes

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