HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 643643Generated: October 31, 2026
Lithium Chloride → Tert-butyl 4-(2-(3-methoxyphenyl)oxazol-4-yl)phenylcarbamate
https://huagongshe.com/reaction/643643
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lithium Chloride | HCID 433294 | — |
| Reactant | Tert-butyl 4-(trimethylstannyl)phenylcarbamate | HCID 19692795 | — |
| Reactant | 2-(3-Methoxyphenyl)oxazol-4-yl trifluoromethanesulfonate | HCID 59262976 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Tert-butyl 4-(2-(3-methoxyphenyl)oxazol-4-yl)phenylcarbamate | HCID 59262979 | 73% |
Reaction Steps
In a sealable tube, 17 (436 mg, 1 eq), tert-butyl 4-(trimethylstannyl)phenylcarbamate (600 mg, 1.25 eq), LiCl (280 mg, 4 eq), Pd(PPh3)4 (77 mg, 5%) were mixed in 10 ml of dioxane. The tube was sealed and heated for 1 night at 100° C., cooled to RT, evaporated and purified by flash chromatography (SiO2, hexane/AcOEt, 85/15) giving 18 as a white solid in 73% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07700616B2 |
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| Source dataset | uspto-grants-2010_04 |
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| ORD ID | ord-353e6c210d474b88819ca5b99aacaeca |
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| Source note | uspto-grants-2010_04 |
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