HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 64365Generated: October 29, 2026
Hydrazine hydrate (1:1) → HCID 136928086, compound
https://huagongshe.com/reaction/64365
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 6-((1,3-Dioxoisoindolin-2-yl)methyl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide | HCID 136928080 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 136928086 | HCID 136928086 | 43.3% |
Reaction Steps
To a solution of 6-((1,3-dioxoisoindolin-2-yl)methyl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide (200 mg, 0.40 mmol) in CH3OH (5 mL) was added hydrazine hydrate (1 mL, 80% of aqueous solution). The mixture was stirred at 70° C. under N2 for 4 hr, concentrated and purified by chromatography column on 5 g of silica gel eluting with DCM/CH3OH to afford 63 mg (43%) of 6-(aminomethyl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide as colorless oil. MS (ESI) m/e [M+1]+ 363.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09447106B2 |
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| Source dataset | uspto-grants-2016_09 |
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| ORD ID | ord-46afa9c29da84fe4ac1f871b9249d57f |
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| Source note | uspto-grants-2016_09 |
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