HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 643671Generated: October 27, 2026
2-Chlorobenzoyl chloride → 7-Bromo-3-(2-chlorophenyl)-[1,2,4]triazolo[4,3-a]pyridine
https://huagongshe.com/reaction/643671
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Chlorobenzoyl chloride | HCID 69110 | — |
| Reactant | 4-Bromo-2-hydrazinylpyridine | HCID 53402863 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 7-Bromo-3-(2-chlorophenyl)-[1,2,4]triazolo[4,3-a]pyridine | HCID 59261369 | — |
Reaction Steps
A mixture of 1-(4-bromopyridin-2-yl)hydrazine (1.00 g, 5.3 mmol) and 2-chlorobenzoyl chloride (8.00 ml, 63 mmol, Aldrich) was heated to 115° C. for 3 h. The mixture was diluted with MeOH and concentrated over SiO2. The residue was purified using column chromatography (MeOH/CH2Cl2=0-10%) yielding the title compound as a tan solid. MS (ESI, pos. ion) m/z: 264.0 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07700593B2 |
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| Source dataset | uspto-grants-2010_04 |
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| ORD ID | ord-b13c72e7b41f4f72893123222bbaa41a |
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| Source note | uspto-grants-2010_04 |
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