Dimethylformamide → HCID 57708174, compound

Participants

Reaction Steps

To a solution of methyl {[1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)-1H-benzimidazol-5-yl]sulfonyl}acetate (Example 1, Step F, 620 mg, 1.64 mmol) in N,N′-dimethylformamide (6.0 mL) was added potassium carbonate (680 mg, 4.91 mmol) and 1,2-dibromoethane (170 μL, 1.97 mmol) at room temperature and stirred for 30 h. The mixture was quenched with water (40 mL) and extracted with ethyl acetate (50 mL×3). The combined organic layers were dried over sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (hexane:ethyl acetate=3:2 as eluent) to afford the title compound (533 mg, 80%) as a white amorphous.

Provenance & Evidence