7-(3-(3-Chloropropanamido)phenyl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide → HCID 136928127, compound

HRID 64370Notes

Reaction equation

HRID 64370 reaction equation
[CH2:1]([N:8]1[CH2:34][C:10]2([CH2:15][N:14]3[N:16]=[C:17]([C:21]4[CH:26]=[CH:25][C:24]([O:27][C:28]5[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=5)=[CH:23][CH:22]=4)[C:18]([C:19]#[N:20])=[C:13]3[NH:12][CH2:11]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.ClCCC(NC1C=C(C2N3N=C(C4C=CC(OC5C=CC=CC=5)=CC=4)C(C(N)=O)=C3NCC2)C=CC=1)=[O:39]>>[CH2:1]([N:8]1[CH2:9][C:10]2([CH2:15][N:14]3[N:16]=[C:17]([C:21]4[CH:26]=[CH:25][C:24]([O:27][C:28]5[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=5)=[CH:23][CH:22]=4)[C:18]([C:19]([NH2:20])=[O:39])=[C:13]3[NH:12][CH2:11]2)[CH2:34]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 1362142937-(3-(3-Chloropropanamido)phenyl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamideHCID 1369280821-Benzyl-2'-(4-phenoxyphenyl)-5',7'-dihydro-4'H-spiro[azetidine-3,6'-pyrazolo[1,5-a]pyrimidine]-3'-carbonitrile

Product 1

HCID 136928127HCID 136928127, compound

Procedure

The desired product was prepared from 1-benzyl-2′-(4-phenoxyphenyl)-5′,7′-dihydro-4′H-spiro[azetidine-3,6′-pyrazolo[1,5-a]pyrimidine]-3′-carbonitrile using the procedure similar to step 2 for compound 2. MS (ESI) m/e [M+1]+ 465.9.

Sources & evidence

ORD record
ord-8c91f422fd514c4ca4d85393de78c43e
Source dataset
uspto-grants-2016_09
Patent number
US09447106B2

Reaction notes

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