HCID 86630625, compound → HCID 68615718, compound

Participants

Reaction Steps

A mixture of 5-[(2-azido-1,1-dimethylethyl)sulfonyl]-1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)-1H-benzimidazole (Step J, 265 mg, 0.66 mmol), 10% palladium carbon (30 mg) and methanol (8 mL) was stirred at room temperature for 18 h under hydrogen atmosphere. The reaction mixture was filtered through a pad of celite and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (dichloromethane:methanol=15:1 as eluent) to afford the title compound (199 mg, 80%) as a white brown solid.

Provenance & Evidence