Sulfuric Acid → HCID 86630626, compound

Participants

Reaction Steps

To a mixture of 1-{[1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)-1H-benzimidazol-5-yl]sulfonyl}-2-methylpropan-2-ol (Step E, 996 mg, 2.63 mmol) and trimethylsilyl cyanide (1.4 mL, 10.5 mmol) was added sulfuric acid (3 mL) at −30° C. The whole was warm to room temperature and stirred for 18 h. To the reaction mixture was added water at 0° C. and stirred for 1 h. Then, the resulting mixture was poured into potassium carbonate aqueous solution (20 mL) at 0° C. and extracted with dichloromethane (30 mL×3). The combined organic layer was dried over sodium sulfate and concentrated to afford the title compound (330 g, 31%) as a white amorphous.

Provenance & Evidence