HCID 86630626, compound → HCID 68615607, compound

Participants

Reaction Steps

A solution of N-(2-{[1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)-1H-benzimidazol-5-yl]sulfonyl}-1,1-dimethylethyl)formamide (Step F, 330 mg, 0.814 mmol) in Hydrogen Chloride, Methanol Reagent 10 (TCI Co.: 4 mL) was stirred at room temperature for 18 h. The reaction mixture was concentrated and the residue was extracted with dichloromethane (30 mL×3). The combined organic layer was washed with saturated sodium hydrogen carbonate aqueous solution (20 mL). The resulting solution was dried over sodium sulfate and concentrated. The residue was purified by column chromatography on silica gel (dichloromethane:methanol=15:1 as eluent) to afford the title compound (199 mg, 65%) as a white amorphous.

Provenance & Evidence