2-Chloro-4-Phenylphenol → 3-(3-Chloro-biphenyl-4-yloxymethyl)-benzoic acid

HRID 643781Notes

Reaction equation

HRID 643781 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:4][C:3]=1[OH:14].C[O:16][C:17](=[O:26])[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24]Br)[CH:19]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:4][C:3]=1[O:14][CH2:24][C:20]1[CH:19]=[C:18]([CH:23]=[CH:22][CH:21]=1)[C:17]([OH:26])=[O:16]

Participants

3

Reactant 2

HCID 70742-Chloro-4-PhenylphenolHCID 517981Methyl 3-(bromomethyl)benzoate

Product 1

HCID 113366873-(3-Chloro-biphenyl-4-yloxymethyl)-benzoic acid

Procedure

3-(3-Chloro-biphenyl-4-yloxymethyl)-benzoic acid was prepared using general procedure A from 2-chloro-4-phenylphenol (available from TCI America, Portland, Oreg.) and 3-(bromomethyl)benzoic acid methyl ester (available from Lancaster Synthesis Ltd., Morcambe, Lancashire, UK). Yield: 76 mg. Mass spectrum MH+=339.

Sources & evidence

ORD record
ord-12deb865ea184b12815f53535d5e4d0d
Source dataset
uspto-grants-2010_04
Patent number
US07700632B2

Reaction notes

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