Methyl 3-(bromomethyl)benzoate → 3-(4'-Methoxy-biphenyl-4-yloxymethyl)-benzoic acid

HRID 643787Notes

Reaction equation

HRID 643787 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.C[O:17][C:18](=[O:27])[C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([CH2:25]Br)[CH:20]=1>>[CH3:15][O:14][C:11]1[CH:12]=[CH:13][C:8]([C:5]2[CH:4]=[CH:3][C:2]([O:1][CH2:25][C:21]3[CH:20]=[C:19]([CH:24]=[CH:23][CH:22]=3)[C:18]([OH:27])=[O:17])=[CH:7][CH:6]=2)=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 517981Methyl 3-(bromomethyl)benzoateHCID 110308394-Hydroxy-4'-methoxybiphenyl

Product 1

HCID 113595593-(4'-Methoxy-biphenyl-4-yloxymethyl)-benzoic acid

Procedure

3-(4′-Methoxy-biphenyl-4-yloxymethyl)-benzoic acid was prepared using general procedure A from 4-hydroxy-4′-methoxybiphenyl (available from TCI America, Portland, Oreg.) and 3-(bromomethyl)benzoic acid methyl ester (available from Lancaster Synthesis Ltd. Morcambe, Lancashire, UK). Yield: 73 mg. Mass spectrum (ES) MH+=335.

Sources & evidence

ORD record
ord-47fa4bd4eb49467c99acb0ff2d60556c
Source dataset
uspto-grants-2010_04
Patent number
US07700632B2

Reaction notes

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