Methyl 5-(chloromethyl)-2-furoate → 5-[[4-(4-methylphenyl)phenoxy]methyl]furan-2-carboxylic Acid

HRID 643790Notes

Reaction equation

HRID 643790 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.C[O:16][C:17]([C:19]1[O:20][C:21]([CH2:24]Cl)=[CH:22][CH:23]=1)=[O:18]>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:24][C:21]3[O:20][C:19]([C:17]([OH:18])=[O:16])=[CH:23][CH:22]=3)=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 75065Methyl 5-(chloromethyl)-2-furoateHCID 13827894-(4-Methylphenyl)phenol2×

Product 1

HCID 71388535-[[4-(4-methylphenyl)phenoxy]methyl]furan-2-carboxylic Acid

Procedure

5-(4′-Methyl-biphenyl-4-yloxymethyl)-furan-2-carboxylic acid was prepared using general procedure A from 4′-methyl-biphenyl-4-ol (purchased from Maybridge plc, Tintagel, Cornwall, UK or from Intermediate 5) and 5-chloromethylfuran-2-carboxylic acid methyl ester (available from Aldrich, Milwaukee, Wis., or from Maybridge plc, Tintagel, UK). Yield: 47 mg. Mass spectrum (ES) MH+=309.

Sources & evidence

ORD record
ord-2f5026a2604944bb92d87ed84515dc78
Source dataset
uspto-grants-2010_04
Patent number
US07700632B2

Reaction notes

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