2-Chloro-4-Phenylphenol → 2-(3-Chloro-biphenyl-4-yloxymethyl)-benzoic acid

HRID 643798Notes

Reaction equation

HRID 643798 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:4][C:3]=1[OH:14].C[O:16][C:17](=[O:26])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[CH2:24]Br>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:4][C:3]=1[O:14][CH2:24][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[C:17]([OH:26])=[O:16]

Participants

3

Reactant 2

HCID 70742-Chloro-4-PhenylphenolHCID 2734813Methyl 2-(bromomethyl)benzoate2×

Product 1

HCID 114391872-(3-Chloro-biphenyl-4-yloxymethyl)-benzoic acid

Procedure

2-(3-Chloro-biphenyl-4-yloxymethyl)-benzoic acid was prepared using general procedure A from 2-chloro-4-phenylphenol (available from TCI America, Portland, Oreg.) and 2-bromomethyl-benzoic acid methyl ester (Intermediate 1). Yield: 45 mg. Mass spectrum (ES) MH+=339.

Sources & evidence

ORD record
ord-aed4a67095ae47b4acfec71cbf7cac1b
Source dataset
uspto-grants-2010_04
Patent number
US07700632B2

Reaction notes

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