Methyl 2-(bromomethyl)benzoate → 2-(2'-Nitro-biphenyl-4-yloxymethyl)-benzoic acid

HRID 643800Notes

Reaction equation

HRID 643800 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[N+:14]([O-:16])=[O:15])=[CH:4][CH:3]=1.C[O:18][C:19](=[O:28])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH2:26]Br>>[N+:14]([C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[C:5]1[CH:6]=[CH:7][C:2]([O:1][CH2:26][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[C:19]([OH:28])=[O:18])=[CH:3][CH:4]=1)([O-:16])=[O:15]

Participants

3

Reactant 2

HCID 2734813Methyl 2-(bromomethyl)benzoate2×HCID 155411124-Hydroxy-2'-nitrobiphenyl

Product 1

HCID 112910122-(2'-Nitro-biphenyl-4-yloxymethyl)-benzoic acid

Procedure

2-(2′-Nitro-biphenyl-4-yloxymethyl)-benzoic acid was prepared using general procedure A from 4′-hydroxy-2-nitrobiphenyl (available from TCI America Portland, Oreg.) and 2-bromomethyl-benzoic acid methyl ester (intermediate 1). Yield: 69 mg. Mass spectrum (ES) MH+=350.

Sources & evidence

ORD record
ord-c52ef6f1ba644e9bbbe770f70485f4c9
Source dataset
uspto-grants-2010_04
Patent number
US07700632B2

Reaction notes

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