Methyl 5-(bromomethyl)thiophene-2-carboxylate → HCID 11314240, compound

HRID 643802Notes

Reaction equation

HRID 643802 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[N+:14]([O-:16])=[O:15])=[CH:4][CH:3]=1.C[O:18][C:19]([C:21]1[S:22][C:23]([CH2:26]Br)=[CH:24][CH:25]=1)=[O:20]>>[N+:14]([C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[C:5]1[CH:6]=[CH:7][C:2]([O:1][CH2:26][C:23]2[S:22][C:21]([C:19]([OH:20])=[O:18])=[CH:25][CH:24]=2)=[CH:3][CH:4]=1)([O-:16])=[O:15]

Participants

3

Reactant 2

HCID 11424851Methyl 5-(bromomethyl)thiophene-2-carboxylate2×HCID 155411124-Hydroxy-2'-nitrobiphenyl

Product 1

HCID 11314240HCID 11314240, compound

Procedure

5-(2′-Nitro-biphenyl-4-yloxymethyl)-thiophene-2-carboxylic acid was prepared using general procedure A from 4-hydroxy-2′-nitrobiphenyl (available from TCI America, Portland, Oreg.) and 5-bromomethyl-thiophene-2-carboxylic acid methyl ester (Intermediate 7). Yield: 80 mg. Mass spectrum (ES) MH+=356.

Sources & evidence

ORD record
ord-e967129c143d4f65bb9f5aaaa38d6fb1
Source dataset
uspto-grants-2010_04
Patent number
US07700632B2

Reaction notes

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