2-Chloro-4-Phenylphenol → 2-(3-Chloro-biphenyl-4-yloxymethyl)-thiazole-4-carboxylic acid

HRID 643805Notes

Reaction equation

HRID 643805 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:4][C:3]=1[OH:14].C([O:17][C:18]([C:20]1[N:21]=[C:22]([CH2:25]Br)[S:23][CH:24]=1)=[O:19])C>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:4][C:3]=1[O:14][CH2:25][C:22]1[S:23][CH:24]=[C:20]([C:18]([OH:19])=[O:17])[N:21]=1

Participants

3

Reactant 2

HCID 70742-Chloro-4-PhenylphenolHCID 11043146Ethyl 2-(bromomethyl)-1,3-thiazole-4-carboxylate2×

Product 1

HCID 113938352-(3-Chloro-biphenyl-4-yloxymethyl)-thiazole-4-carboxylic acid

Procedure

2-(3-Chloro-biphenyl-4-yloxymethyl)-thiazole-4-carboxylic acid was prepared using general procedure B from 2-chloro-4-phenylphenol (available from TCI America, Portland, Oreg.) and 2-bromomethyl-thiazole-4-carboxylic acid ethyl ester (Intermediate 3). Yield: 82 mg. Mass spectrum (ES) MH+=346.

Sources & evidence

ORD record
ord-77fb3687e8d74c79b5cbbdf23fc0323f
Source dataset
uspto-grants-2010_04
Patent number
US07700632B2

Reaction notes

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