3-Phenylphenol → 2-(Biphenyl-3-yloxymethyl)-thiazole-4-carboxylic acid

HRID 643806Notes

Reaction equation

HRID 643806 reaction equation
[C:1]1([C:7]2[CH:8]=[C:9]([OH:13])[CH:10]=[CH:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C([O:16][C:17]([C:19]1[N:20]=[C:21]([CH2:24]Br)[S:22][CH:23]=1)=[O:18])C>>[C:7]1([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH:12]=[CH:11][CH:10]=[C:9]([O:13][CH2:24][C:21]2[S:22][CH:23]=[C:19]([C:17]([OH:18])=[O:16])[N:20]=2)[CH:8]=1

Participants

3

Reactant 2

HCID 113813-PhenylphenolHCID 11043146Ethyl 2-(bromomethyl)-1,3-thiazole-4-carboxylate2×

Product 1

HCID 112438642-(Biphenyl-3-yloxymethyl)-thiazole-4-carboxylic acid

Procedure

2-(Biphenyl-3-yloxymethyl)-thiazole-4-carboxylic acid was prepared using general procedure B from 3-phenylphenol (available from Aldrich, Milwaukee, Wis.) and 2-bromomethyl-thiazole-4-carboxylic acid ethyl ester (Intermediate 3). Yield: 65 mg. Mass spectrum (ES) MH+=312.

Sources & evidence

ORD record
ord-e887853d3d9341c1ae4f9edb0fa711ce
Source dataset
uspto-grants-2010_04
Patent number
US07700632B2

Reaction notes

Loading…