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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 643807Generated: October 25, 2026

4-(4-Methylphenyl)phenol → 2-(4'-Methyl-biphenyl-4-yloxymethyl)-thiazole-4-carboxylic acid

https://huagongshe.com/reaction/643807

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(4-Methylphenyl)phenolHCID 1382789—
ReactantEthyl 2-(bromomethyl)-1,3-thiazole-4-carboxylateHCID 11043146—
Product2-(4'-Methyl-biphenyl-4-yloxymethyl)-thiazole-4-carboxylic acidHCID 11313360—

Reaction Steps

2-(4′-Methyl-biphenyl-4-yloxymethyl)-thiazole-4-carboxylic acid was prepared using general procedure B from 4′-methyl-biphenyl-4-ol (purchased from Maybridge plc, Tintagel, Cornwall, UK or from Intermediate 5) and 2-bromomethyl-thiazole-4-carboxylic acid ethyl ester (intermediate 3). Yield: 70 mg. Mass spectrum (ES) MH+=326.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07700632B2
Source datasetuspto-grants-2010_04
ORD IDord-7d3cae91eb224f8499fe64dc91093f0c
Source noteuspto-grants-2010_04