4-Bromo-4'-hydroxybiphenyl → HCID 11257785, compound

HRID 643808Notes

Reaction equation

HRID 643808 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.C([O:17][C:18]([C:20]1[N:21]=[C:22]([CH2:25]Br)[S:23][CH:24]=1)=[O:19])C>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:25][C:22]3[S:23][CH:24]=[C:20]([C:18]([OH:19])=[O:17])[N:21]=3)=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 950934-Bromo-4'-hydroxybiphenylHCID 11043146Ethyl 2-(bromomethyl)-1,3-thiazole-4-carboxylate2×

Product 1

HCID 11257785HCID 11257785, compound

Procedure

2-(4′-Bromo-biphenyl-4-yloxymethyl)-thiazole-4-carboxylic acid was prepared using general procedure B from 4-bromo-4′-hydroxybiphenyl (available from TCI America, Portland, Oreg.) and 2-bromomethyl-thiazole-4-carboxylic acid ethyl ester (Intermediate 3). Yield: 82 mg. Mass spectrum (ES) MH+=390.

Sources & evidence

ORD record
ord-88f0c97c93c64f8dae51f2c83608594b
Source dataset
uspto-grants-2010_04
Patent number
US07700632B2

Reaction notes

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