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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 643819Generated: November 2, 2026

Toluene → 1-{[4-(7-Methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid ethyl ester

https://huagongshe.com/reaction/643819

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTolueneHCID 1140—
ReactantHCID 20765329HCID 20765329—
SolventTrifluoroacetic acid methylene chlorideHCID 21863450—
Product1-{[4-(7-Methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid ethyl esterHCID 20765316—

Reaction Steps

Compound 5 was kept in TFA-DCM 1:2 (3 mL) at RT for 60 min. Toluene (3 mL) was added. The sample was co-evaporated to dryness. Purity by HPLC >95%. M+H+ 502.4.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07700552B2
Source datasetuspto-grants-2010_04
ORD IDord-fa7d77a5ac744afb9779250c6b3cdebc
Source noteuspto-grants-2010_04