Acetyl chloride → 1-(2-Amino-4-methoxyphenyl)ethan-1-one

Temperature

-50 °C

m-Anisidine (10.0 g, 82 mmol) was dissolved in CH2Cl2 (50 mL), and the solution was cooled to −50° C. BCl3 (1 M in CH2Cl2, 82 mL, 82 mmol) was added slowly during 20 min, after which the mixture was stirred at −50° C. for 30 min, followed by sequential addition of AcCl (6.0 mL, 84 mmol) and AlCl3 (11 g, 82 mmol). The mixture was stirred at −50° C. for 1 h and was then allowed to assume rt. After stirring at rt overnight, the solution was heated at 40° C. for 4 h, after which the mixture was poured over ice. The aqueous mixture was made alkaline with 10% NaOH (w/v) and extracted with EtOAc (4×200 mL). The combined organic phases were washed with brine, dried (MgSO4), and evaporated to give a black solid, which was purified by flash column chromatography (ether/CH2Cl2 20:80). The resulting solid was recrystallized from ether/hexane to give the title compound as shiny tan leaflets (5.6 g, 42%).

1. stirringThe mixture was stirred at −50° C. for 1 h
2. customto assume rt
3. stirringAfter stirring at rt overnight
4. temperaturethe solution was heated at 40° C. for 4 h
5. additionafter which the mixture was poured over ice
6. extractionextracted with EtOAc (4×200 mL)
7. washThe combined organic phases were washed with brine
8. dry with materialdried (MgSO4)
9. customevaporated
10. customto give a black solid, which
11. customwas purified by flash column chromatography (ether/CH2Cl2 20:80)
12. customThe resulting solid was recrystallized from ether/hexane

ORD record

ord-10eeaa07beb74fa09f49a6f090c83fc1

Source dataset

uspto-grants-2010_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07700552B2