反应详情

Compound 16 (200 mg, 0.26 mmol) was dissolved in degassed dichloromethane (30 ml). Hoveyda-Grubbs catalyst II generation (16 mg, 0.026 mmol) was then added and the mixture was refluxed under argon atmosphere overnight. The solvent was then evaporated and the crude product was purified by silica chromatography (1% methanol in ether) which gave the title compound (39 mg, 20%). MS (M+H+) 728.2.

1. temperaturethe mixture was refluxed under argon atmosphere overnight
2. customThe solvent was then evaporated
3. customthe crude product was purified by silica chromatography (1% methanol in ether) which