Sodium Hydroxide → 4-Chloro-2-[4-(propan-2-yl)-1,3-thiazol-2-yl]quinazoline

Participants

Reaction Conditions

Reaction Steps

Compound 50 (100 mg, 0.37 mmol) was added to phosphorous oxychloride (2 mL) and heated to 100° C. for 2 h. The reaction mixture was then poured on ice with vigorous stirring and made basic with NaOH (aq). The resulting slurry was extracted with ether (3×20 mL) and the combined organic phases were dried (MgSO4) and filtered. Removal of the solvent in vacuo afforded the title compound in quantitative yield. LC/MS>95%, m/z (ESI+)=290 (MH+).

Provenance & Evidence