Hydrochloric Acid → HCID 66750577, compound

Participants

Reaction Steps

Benzhydrylidene-(3,6-bis-benzyloxynaphthalen-2-yl)-amine (0.628 g, 1.208 mmol) is dissolved in 15 mL of THF. A solution of 1 N HCl (15 mL) is added and stirred for 30 min. The crude reaction mixture is basified to pH 14 with 1 N NaOH and extracted with EtOAc. The combined organic layers are dried and evaporated to afford an orange oil. The oil is purified on silica, eluting with 9:1 hexanes/EtOAc and then 1:1 hexanes/EtOAc, to afford 3,6-bis-benzyloxynaphthalen-2-ylamine.

Provenance & Evidence