Hydrochloric Acid → HCID 66750729, compound

Participants

Reaction Conditions

Reaction Steps

3,6-Bis-benzyloxynaphthalen-2-ylamine (0.332 g, 0.934 mmol) is dissolved in DMF (5 mL). Ethyl bromoacetate (0.114 mL, 1.03 mmol) and potassium carbonate (0.194 g, 1.40 mmol) are added. The reaction is heated to 60° C. for 3 h and then poured into 1 N HCl and extracted with EtOAc. The combined organic layers are washed with brine, dried and evaporated to a red foam, which is purified over silica, eluting with 8:1 hexanes/MTBE, to afford (3,6-bis-benzyloxynaphthalen-2-ylamino)-acetic acid ethyl ester as a yellow solid.

Provenance & Evidence