Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | tert-Butyl bromoacetate | HCID 79177 | — |
| Reactant | HCID 22173744 | HCID 22173744 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 66750567 | HCID 66750567 | — |
Reaction Steps
A mixture of 3,7-dihydroxynaphthalene-2-carboxylic acid methyl ester (3.32 g, 15.5 mmol), bromoacetic acid tert-butyl ester (2.29 mL, 15.5 mmol) and potassium carbonate (4.28 g, 31.0 mmol) in DMF (20 mL) is stirred at 60° C. for 18 h. The reaction mixture is poured to EtOAc, wash with water and brine. It is then dried with MgSO4 and concentrated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07700633B2 |
|---|
| Source dataset | uspto-grants-2010_04 |
|---|
| ORD ID | ord-2d2f939adb0d4254b87d1e09a8b2ceb0 |
|---|
| Source note | uspto-grants-2010_04 |
|---|
