Water → HCID 66751020, compound

HRID 643880Notes

Reaction equation

HRID 643880 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:14]([OH:15])=[CH:13][C:12]2[C:7](=[CH:8][C:9]([O:16][CH2:17][C:18]([O:20]C(C)(C)C)=[O:19])=[CH:10][CH:11]=2)[CH:6]=1)=[O:4].O>C(O)=O>[CH3:1][O:2][C:3]([C:5]1[C:14]([O:15][CH2:3][C:5]2[CH:14]=[CH:13][CH:12]=[CH:7][CH:6]=2)=[CH:13][C:12]2[C:7](=[CH:8][C:9]([O:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:10][CH:11]=2)[CH:6]=1)=[O:4]

Participants

4

Reactant 2

HCID 962WaterHCID 66750567HCID 66750567, compound

Product 1

HCID 66751020HCID 66751020, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

7-tert-butoxycarbonylmethoxy-3-hydroxynaphthalene-2-carboxylic acid methyl ester (1.35 g, 3.2 mmol) in formic acid (5 mL) is stirred at RT for 2 h. The mixture is poured into water, filtered and washed with water. After it is air dried for 18 h, it is dissolved in EtOAc, dried with MgSO4, concentrated to give the title compound.

Workup

  1. filtrationfiltered
  2. washwashed with water
  3. customdried for 18 h
  4. dissolutionit is dissolved in EtOAc
  5. dry with materialdried with MgSO4
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-af8c83ceeb5e4b7b898e370665ff4ef2
Source dataset
uspto-grants-2010_04
Patent number
US07700633B2

Reaction notes

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