Diisopropylethylamine → HCID 17751325, compound

Participants

Reaction Steps

To a solution of 5-[6-hydroxy-7-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-naphthalen-2-yl]-2,2-dimethylpentanoic acid (Example LCE840, 63 mg, 0.13 mmol) in MeOH at 0° C. is added DIEA (0.032 mL, 0.13 mmol). After is stirred for 2 min, trimethylsilyldiazomethane (2M, 0:07 mL) is added drop wise. The reaction mixture is stirred for 15 min and concentrated give the title compound: Retention time=1.28 min (Method A); (M−H)−=419.

Provenance & Evidence