Pyridine → HCID 13963106, compound

HRID 643885Notes

Reaction equation

HRID 643885 reaction equation
[CH3:1][CH:2](O)C=C.[C:6]([O:9][C:10](=O)[CH3:11])(=[O:8])[CH3:7].N1C=CC=C[CH:14]=1>>[CH3:14][CH:11]([CH:1]=[CH2:2])[CH2:10][O:9][C:6](=[O:8])[CH3:7]

Participants

4

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 117163-Buten-2-ol

Product 1

HCID 13963106HCID 13963106, compound

Conditions

Temperature
50 °C

Procedure

To a solution of but-3-en-2-ol (0.16 mL, 1.6 mmol) in pyridine (1 mL) is added acetic anhydride (0.28 mL, 1.6 mmol) and the mixture is heated at 50° C. for 18 h. Pyridine is removed by washing with Et2O and 1 N HCl solution, followed by sat. CuSO4, water and brine. The organic layer is dried with NaSO4 and concentrated to give the title compound.

Workup

  1. customPyridine is removed
  2. washby washing with Et2O and 1 N HCl solution
  3. dry with materialThe organic layer is dried with NaSO4
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-c0aef86501e2426bba1a800b97ef0977
Source dataset
uspto-grants-2010_04
Patent number
US07700633B2

Reaction notes

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