(3-(Aminomethyl)phenyl)boronic acid → 5-[7-(3-Aminomethylphenyl)-3-benzyloxynaphthalen-2-yl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one

HRID 643888Notes

Reaction equation

HRID 643888 reaction equation
[NH2:1][CH2:2][C:3]1[CH:4]=[C:5](B(O)O)[CH:6]=[CH:7][CH:8]=1.[CH2:12]([O:19][C:20]1[C:21]([N:31]2[S:35](=[O:37])(=[O:36])[NH:34][C:33](=[O:38])[CH2:32]2)=[CH:22][C:23]2[C:28]([CH:29]=1)=[CH:27][CH:26]=[C:25](Br)[CH:24]=2)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[NH2:1][CH2:2][C:3]1[CH:4]=[C:5]([C:25]2[CH:24]=[C:23]3[C:28]([CH:29]=[C:20]([O:19][CH2:12][C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)[C:21]([N:31]4[S:35](=[O:36])(=[O:37])[NH:34][C:33](=[O:38])[CH2:32]4)=[CH:22]3)=[CH:27][CH:26]=2)[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 2773203(3-(Aminomethyl)phenyl)boronic acidHCID 667506335-(3-(Benzyloxy)-7-bromonaphthalen-2-yl)-1,2,5-thiadiazolidin-3-one 1,1-dioxide

Product 1

HCID 667509055-[7-(3-Aminomethylphenyl)-3-benzyloxynaphthalen-2-yl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one

Procedure

5-[7-(3-Aminomethylphenyl)-3-benzyloxynaphthalen-2-yl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one is prepared according to the general procedure outlined in Example 4, step A, starting with (3-aminomethylphenyl)boronic acid and 5-(3-benzyloxy-7-bromonaphthalen-2-yl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one: (M−H)−=472.

Sources & evidence

ORD record
ord-51569bd2400947ad8c7100e7efcd3db5
Source dataset
uspto-grants-2010_04
Patent number
US07700633B2

Reaction notes

Loading…