Potassium Carbonate → HCID 68700548, compound

Participants

Reaction Steps

A mixture of 5-(3-benzyloxy-6-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one (158 mg, 0.40 mmol), intermediate from Example 45, chloromethoxymethylbenzene (0.068 mL, 0.49 mmol) and potassium carbonate (110 mg, 0.80 mmol) in DMF (4 mL) is stirred at RT for 18 h. The mixture is partitioned between EtOAc and 1 N HCl solution. The organic extract is dried with MgSO4 and concentrated. The residue is purified by chromatography to give the title compound as an oil: (M+NH4)+=526.

Provenance & Evidence