Water → HCID 66750495, compound

HRID 643910Notes

Reaction equation

HRID 643910 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[CH:8]([CH3:14])[CH2:7][CH2:6]2.[BH4-].[Na+].O>CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]([OH:13])[CH:8]([CH3:14])[CH2:7][CH2:6]2

Participants

5

Reactant 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 111168446-Methoxy-2-methyl-1-tetralone

Product 1

HCID 66750495HCID 66750495, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To an ice-cooled solution of 6-methoxy-2-methyl-3,4-dihydro-2H-naphthalen-1-one (7.0 g, 36.8 mmol) in MeOH (120 mL) is added NaBH4 (2.78 g, 73.6 mmol) portion wise and the mixture is stirred at RT for 20 min. Then the reaction is poured to 120 mL of water and extracted with ether. The organic phase is dried with MgSO4, concentrated to give the title compound as a light yellow oil and it is used in the next step without purification.

Workup

  1. extractionextracted with ether
  2. dry with materialThe organic phase is dried with MgSO4
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-05bd5e8748984941a461d387e32a9b1b
Source dataset
uspto-grants-2010_04
Patent number
US07700633B2

Reaction notes

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